T's and blues noun a combination of Taluin, a painkiller, and the antihistamine Pyribenzamine, abused for non-medicinal purposes US
— Geoffrey Froner, DiggingforDiamonds, p. 60, 1989
Tops and Bottoms is street slang for T’s and Blues. T’s are Taluin, a painkiller, and Blues are Pyribenzamine, an antihistamine. Combined in the right dosage they make a poor man’s heroin. — ChicagoTribune, p. 6C, 11 June 1989