the odds are against something/somebody doing something

(the) odds are against (something)

It is very unlikely or improbable that (something is the case or will happen). I'm really happy that we've been nominated, but, if I'm being honest, the odds are against us winning. Odds are against a bipartisan deal, but many are remaining hopeful going into the vote.
See also: odds
Farlex Dictionary of Idioms.

the odds are aˈgainst something/somebody doing something

something is very unlikely: The odds are against them winning, I’m afraid. The odds are against her because she’s less experienced than the other applicants.
See also: odds, somebody, something
Farlex Partner Idioms Dictionary
See also:
  • (the) odds are against (something)
  • be more than (something)
  • be more than glad, ready, etc.
  • be in it for
  • be at a disadvantage
  • at a disadvantage
  • address (one's) comments to (someone or something)
  • address comments or remarks to
  • address (one's) remarks to (someone or something)
  • away from it all