out of (one's) brain

out of (one's) brain

Heavily intoxicated by drugs or alcohol, especially to the point of becoming unconscious, nonsensical, or out of control. Primarily heard in UK. I think someone might have spiked Jack's drink with some kind of drug, because he's out of his brain all of a sudden. Jane is a lightweight. Only one or two beers gets totally out of her brain. I had to take my brother away from the party because he was out of his brain on LSD.
See also: brain, of, out
Farlex Dictionary of Idioms.
See also:
  • be out of (one's) brain
  • be out of (one's) face
  • out of (one's) face
  • out of (one's) skull
  • out of one’s skull
  • out of skull
  • out of your skull
  • skull
  • be out of (one's) skull
  • hold liquor