louse something up

louse up

To ruin, spoil, mess up, or bungle someone or something. A noun or pronoun can be used between "louse" and "up." Her sudden decision to quit in the middle of the project really loused us up. I am not letting your crummy attitude louse up my vacation—if you want to be grouch, you can go somewhere else and do it alone!
See also: louse, up
Farlex Dictionary of Idioms.

louse something up

tv. to botch something up. Please don’t louse the typewriter ribbon up this time.
See also: louse, something, up
McGraw-Hill's Dictionary of American Slang and Colloquial Expressions
See also:
  • louse (something) up, to
  • louse up
  • crap up
  • bungle up
  • scupper up
  • futz something up
  • futz up
  • not do (someone or oneself) any favors
  • rescue from
  • rescue from (someone or something)