Give it up!

give it up

To stop doing something. Often used as an imperative. Give it up—Adam's a better skateboarder than you, and no amount of practice will change that. Oh, give it up already—I know you're lying.
See also: give, up
Farlex Dictionary of Idioms.

Give it up!

Inf. Stop trying!; You are wasting your time! (Fixed order.) Bob: I just can't understand calculus! Bill: Give it up! Get out of that course and get into something less cruel. Tom: I'm just not a very good singer, I guess. Sue: It's no good, Tom. Give it up! Tom: Don't you think I'm doing better, though? Sue: Give it up, Tom!
See also: give
McGraw-Hill Dictionary of American Idioms and Phrasal Verbs.

Give it up!

exclam. Quit now!; Enough is enough! Give it up! You can’t pitch!
See also: give
McGraw-Hill's Dictionary of American Slang and Colloquial Expressions
See also:
  • give it up
  • give up
  • cough it up
  • Cough it up!
  • come in
  • come in a certain position
  • come on in
  • break it up
  • Break it up!
  • break up