1. An onomatopoeic interjection representing a sudden cessation, disappearance, or ending (of something). (Meant to simulate the sound of something disappearing in a puff of smoke.) One day, we all had jobs, not thinking too hard about what the future would bring, when all of a sudden—pfft! The company closes down, and we're left with nothing. I can't believe you're willing to let our friendship disintegrate over one argument. Pfft, just like that?

2. A sarcastic interjection signifying one's disagreement with or dismissal of something that's been said or done. A: "They're going to want you to sign a statement pledging your devotion to the company." B: "Pfft! I'm not signing that!" A: "He said he was going to beat you up." B: "Pfft—as if he could!"