1. To begin (something) with someone or something. In this usage, a noun or pronoun can be used between "lead" and "with." Let's lead with the comedian to lighten up the crowd before we bring on the rest of the acts. You should have led with how much money you expect your project to make—the investors would have been much more receptive from the get-go. They led the news with a story about the president's visit to India.

2. To choose a particular athlete or group of athletes with whom to begin a competition or sporting event. The team is leading with their star batter. In a surprise move, the coach is leading with the youngest members of the team for kickoff.

3. In boxing, to use a particular hand or type of punch when beginning an attack. Your next opponent tends to lead with his left, so you'll want to adapt your stance to be better able to dodge it. He led with a quick jab before connecting a devastating uppercut.