1. To be out of equilibrium; to not be straight, level, or aligned properly; to be in a state of chaos or confusion. I've been out of kilter ever since I got that blow to the head during football practice. The economy is still out of kilter in many countries across Europe, even as the global economy has started to recover.

2. To not work correctly or properly; to be out of order; to be out of w(h)ack. It sounds like your car's engine is a bit out of kilter. I'd recommend taking it to a mechanic before you go for any long drives.