1. In constant pursuit of one, as to hurt or apprehend them. The schizophrenic patient had delusions that the FBI were out to get him. The cops are out to get the guy who robbed the coffee shop.

2. Having an agenda to harass, castigate, or harm the reputation of one. The senator continues to claim that the media is out to get him. I'm worried that one of my co-workers is out to get me—I think he really wants my job.