1. To do things that create a very strong emotional reaction in someone, especially anger, irritation, or exasperation. I hate Dave's new boyfriend—he's always trying to press my buttons, and he's doing a good job of it! No one will be able to press your buttons like your children, but it's all a part of the adventure of parenthood.

2. To be sexually attractive or arousing to someone. Did you see that waitress over at the other table? Man, she presses my buttons.