1. vulgar slang To have sexual intercourse with a virgin, especially a female. Before you go busting a girl's cherry, you had better make damn sure that you and she are both totally ready to sleep with each other.

2. vulgar slang To have sex for the first time. There is nothing wrong with waiting until you're absolutely ready before you bust your cherry. Too many people try to pressure you into it from too young an age.

3. vulgar slang By extension, to do something for the first time, often that which is particularly daunting, difficult, dangerous, illicit, etc. Somebody pass Marcus the joint, he still needs to bust his cherry tonight! For her birthday, I bought my friend Samantha a voucher so she could bust her cherry sky diving.