1. rude slang An abbreviation for "get the fuck out," an angry imperative for someone to leave, leave one alone, or stop what they is doing. If she's going to make snarky comments about my food, then she can just GTFO.

2. rude slang An abbreviation for "get the fuck out" used to express surprise at what one has just been told. Although the use of "fuck" can be offensive, this usage of the phrase is not intended to be rude. You got the job? GTFO! A: "You know, your crush is coming to the party after all." B: "What? GTFO!"