1. To lose moisture. In this usage, a noun or pronoun can be used between "dry" and "up." Hey, if you don't want that marker to dry up, put the cap back on it!

2. To remove wetness from something. In this usage, a noun or pronoun can be used between "dry" and "up." Let me get you a towel so you can dry up that spill.

3. To heal a skin rash or irritation. In this usage, a noun or pronoun can be be used between "dry" and "up." Don't worry, the doctor prescribed something that should dry up this rash.

4. Of a skin rash or irritation, to become healed. If your poison ivy doesn't dry up in a few weeks, you should see a dermatologist.

5. To go away or leave. Oh, dry up and give me some peace and quiet!

6. To stop talking; to be quiet. Typically used as an imperative. Oh, dry up already! I'm sick of hearing you complain.