1. rude slang Cheated or swindled; unfairly deprived or taken advantage of. I always bring my dad with me when I go to get my car repaired, because I'm always nervous I'll end up getting screwed. We should have won that game, but we were really screwed by the ref.

2. rude slang Having no chance of success or recovery; in a hopeless or unsalvageable position or situation. Man, we are totally screwed if we can't get this prototype working before the big presentation. After yet another flop on the market, the tech company is seeming pretty screwed these days. The cancer has metastasized in my bones, so the doctors all but told me I'm screwed.

3. vulgar slang Having had sex with someone. You're way too uptight, dude. You need to go out to a bar, pick up a chick, and get screwed.

4. slang Drunk. If you can't make it through a single weekend without getting screwed, then you might need some help with your drinking.