1. verb, vulgar slang Literally, to urinate on someone or something. Her dog walked right over and pissed on me. He was so drunk that he just started pissing on the street where he stood.

2. interjection, vulgar slang An exclamation of disgust, frustration, exasperation, or irritation with someone or something. Jerry doesn't want to contribute to the project? Well, piss on him, then. Piss on this thing! I've been trying to open my browser for 20 minutes, but the computer is totally frozen!

3. interjection, vulgar slang An exclamation of reckless determination; to hell with the consequences. Always used in the form "piss on it." A: "You sure you don't want a beer?" B: "Oh, piss on it—open one up for me. I guess I'll just deal with a hangover at work tomorrow." She stood looking down where her friends had jumped into the river. "Piss on it," she thought, as she took a running leap off the edge.