1.(in charge)负责的
2.(to blame)应负责的；负有责任的
Try to find out who's responsible.搞清楚谁应该负责任。
3.(sensible)明白是非的；能担负责任的；可靠的
You should be more responsible.你应该更加明白是非。
He's a very responsible sort of person.他是一个很有担当的人。
4.to be responsible to sb
(accountable to)向某人负责
The senior members of the department are responsible to me.本部门的高级成员向我负责。
5.(involving important decisions)责任重大的
Being a doctor is a very responsible job.当医生是一个责任极其重大的工作。