What's (up) with (something)?

What's (up) with (something)?

1. What is the meaning or purpose of the something; why is something happening or the case? What's with these tiny portions? For how much the food costs, I was expecting to get a bit more on the plate. We've been waiting to hear what's up company's new expansion plan.
2. What is wrong with something? Hey, what's with your computer? The screen just keeps flashing when I turn it on.
Farlex Dictionary of Idioms.

What's with someone or something?

Why is someone or something in that condition?; What's going on with someone or something? Mary: What's with Tom? He looks depressed. Bill: He broke up with Sally. "What's with this stupid coffee maker? It won't get hot!" groused Alice.
McGraw-Hill Dictionary of American Idioms and Phrasal Verbs.

what's with

Also, what's up with; what gives with. What is going on with; tell me about or explain it. For example, What's with all the food they're giving away? or What's up with Lee these days? or What gives with Jack? Why is he so glum? This idiom is also sometimes used as a substitute for how are you or what's wrong, as in Hi, Pam, what's with you? or What gives with you-why are you yelling? [Colloquial; c. 1940]
The American Heritage® Dictionary of Idioms by Christine Ammer.

what’s with something?

(American English, spoken) used to ask the reason for something: What’s with all this walking? Can’t we take a cab?
Farlex Partner Idioms Dictionary

What’s with someone/something?

interrog. What is wrong with someone or something? What’s with this can opener? It won’t turn.
See also: someone
McGraw-Hill's Dictionary of American Slang and Colloquial Expressions
See also:
  • a/the feel of (something)
  • (I) wouldn't (do something) if I were you
  • a straw will show which way the wind blows
  • a crack at (someone or something)
  • all right
  • (you) wanna make something of it?
  • all for the best
  • a thing of the past
  • a slew of (something)
  • a bird in the hand