hit (someone) where it hurts (most)

to do something which will upset someone as much as possible.

She hit him where it hurt most - in his bank account.

If you want to hit her where it really hurts, tell her she's putting on weight again.

• have guts for garters
• have had a bellyful of
• have had a bellyful of something
• have had a good innings
• have had chips
• have had day
• have had fill
• have had fill of
• have had fill of something
• have had it
• have had its chips
• have had its day
• have had it up to here
• have had it with
• have had it with someone
• have had it with something
• have had more something than has had hot dinners
• have had more something than someone has had hot dinners
• have had more than fair share of
• have had more than fair share of something
• have had more than has had hot dinners
• have had more than someone has had hot dinners
• have had more than your fair share of
• have had more than your fair share of something
• have had your chips