if something runs its course, it continues naturally until it has finished.

Many people believe that feminism has run its course.

The doctor insisted I rest for a few days while the infection ran its course.

• make someone sit up and take notice
• make someone's mouth water
• make someone's skin crawl
• make someone's toes curl
• make something of
• make something of yourself
• make something out of nothing
• make something seem like a picnic
• make something stick
• make something up out of whole cloth
• make something worth while
• make something worth your while
• make stick
• make the bed
• make the best of
• make the best of a bad situation
• make the best of something
• make the grade
• make the headlines
• make the most of
• make the most of something
• make the right noises
• make the rounds
• make the running
• make the scene