to leave your job for ever.

When I stop enjoying my work, that'll be the time to hang up my hat.

• be in a hole
• be in a jam
• be in a lather
• be in another world
• be in a pickle
• be in apple-pie order
• be in a pretty pickle
• be in a right pickle
• be in a rut
• be in a spin
• be in a stew
• be in a tight corner
• be in a tight spot
• shit out of you
• shit-stirrer
• shoe is on the other foot
• shoo-in
• shoot a dirty look
• shoot blanks
• shoot bolt
• shoot daggers at
• shoot daggers at someone
• shoot down
• shoot down in flames
• shoot down something