prey on prey on (someone) 1. to commit a crime against someone. Police are looking for street criminals who prey on tourists. Gangs that prey upon small business owners in the city's Chinatown may be spreading to the suburbs. 2. to have an effect on someone. Guilt preyed on him for years after the accident. Usage notes: sometimes said about something that has an effect on people's emotions: The ads prey on our fear of being alone. |