to be badly affected by something.

His reputation has taken quite a knock following the revelations published in his recent biography.

• out of the frying pan into the fire
• out of the gate
• out of their rut
• out of the loop
• Out of the mouths of babes .
• Out of the mouths of babes and sucklings.
• out of the picture
• out of the question
• out of the running
• out of the starting blocks
• out of the starting gate
• out of the top drawer
• out of the way
• out-of-the-way
• out of thin air
• out of this world
• out of touch
• out of touch with
• out of touch with someone
• out of touch with something
• out of way
• out of whack
• out of whole cloth
• out of your depth
• out of your hands